Calculate the following ratio( profitability raitos )for Shire from the annual report for 2016 and explain what every ratio indicate :

a) Gross Margin Ratio

b) Profit Margin Ratio

c) Return On Assets Ratio

d )Return on common stockholders equity

e)Asset Turnover

f) Earnings Per Share

g)Price-Earnings (P-E) Ratio

h) Payout Ratio