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Can you guys please show th calciulations of how the etext arrived at certain answers. Most of the numbers were plug in out of no
Can you guys please show th calciulations of how the etext arrived at certain answers. Most of the numbers were plug in out of no where without a calculation of how it is gotten.Please show a solved calcuclation
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Example 25.12 Finding the resistance and resistivity of a cell membrane Researchers use microelectrodes to measure the ion currents into and out of cells. When a neuron is in its resting state, the current into a 1mmlong segment of its 5pm-diameter axon is z 3 nA. a. What are the equivalent resistance and the resistivity of the axon's membrane? b. Measuring individual ion leak channels is difcult, but it's thought that the current through each channel is z 0.1 pA. How many leak channels are in this lmm-long segment? What is their density in channels per ,umz? PREPARE The membrane of an axon, as seen in Figure 25.41 ID, is a thin-walled cylindrical shell that has radius R, length L, and thickness d. We can imagine unrolling the cylinder to obtain a thin, at sheet of membrane of width 271R (the cylinder's circumference), length L, and thickness d. Vmem is the potential difference across this sheet, and current I passes through from outside the cell to inside. We know from Chapter 24E that the resistance of a conductor of thickness d and cross-section area A is R = pd/A, where p is the resistivity. a. We can use Ohm's law to calculate the equivalent resistance of the membrane: Rmem I Vmem 0.070 V ~ 2 X 10' 2 = 20 MQ 3 X 10-9 A The data are not precisely known, so one-significant-figure answers are appropriate. The membrane's resistivity is P ARmen (2nRL)Rmen 2x(2.5 x 10- m)(0.001 m)(2 x 10'S) 7 x 10- m = 4x 10 2 . m b. The total current that passes into the cell through N leak channels is /total = NIchan. Thus, the number of channels is total 3 X 10-9 A N= - ~ = 3 x 104 Ichan 1 x 10-13 A These 30,000 channels are spread out over the surface area A = 2TRL of this segment of the axon, so the surface density of channels is N 3 x 104 channels 2TRL 2x(2.5 x 10- m)(0.001 m) = 2 x 10 2 channels/m~ x 10-6 m 1 um = 2 channels/umStep by Step Solution
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