Question
Can you please synthesize and summarzie the following passage about the limitations of the cox model. The Cox hazards model differs from the classical regression
Can you please synthesize and summarzie the following passage about the limitations of the cox model.
The Cox hazards model differs from the classical regression model because it introduces time-dependent censored variables for cases when the analyzed end point does not occur during observation. As a result, it is not possible to calculate the so-called "model residuals", i.e. the differences between the real and expected values of dependent variables. However, it is possible to check the assumptions in a non-parametric hazards model if one uses Schoenfeld residuals, test 2 and the Rho coefficient of rank correlation between residuals and time. Obtaining a horizontal regression line of residuals across the time axis confirms the proportionality of hazard (Abeysekera et al., 2009; Grambsch et al., 1994; Keele, 2010; Schoenfeld, 1982; Winett et al., 2001). Unfortunately, this important assumption has been checked and properly reported in very few scientific publications.
It is improper to use a simple Cox regression model with regard to the violation of proportional hazard assumptions as it can lead to false deductions. Using a regression model with stratification of variables (the so-called stratified model) or an extended regression model with time dependent variables, which is one of the so-called non-proportional hazards models, is recommended.
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