Cappelletti and Wallen (2016) criticized the commercial promotion of testosterone-replacement therapy for women who had undergone hysterectomies and/or ovariectomies in order to restore sexual motivation and behavior. One of their criticisms was that:

1. estrogen was the sole hormone that could restore sexual motivation and behavior, not testosterone
2. the doses required to be effective were much larger than those that were found naturally (in control group women or those who had not undergone surgeries)
3. human female sexual motivation and behavior were unrelated to circulating hormone levels or concentrations
4. the side effects of hormone replacement therapies were far greater than the benefits produced

2. With regard to the neural control of female sexual behavior, where in the brain does estrogen (and progesterone) have activating effects?

1. medial preoptic area
2. lateral preoptic area
3. dorsolateral thalamus
4. ventromedial hypothalamus