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Calculate charged and uncharged ration of weak acid and weak base drug under normal and basic urine pH. What is the effect of urine

Calculate charged and uncharged ration of weak acid and weak base drug under normal and basic urine pH. What is the effect of

Calculate charged and uncharged ration of weak acid and weak base drug under normal and basic urine pH. What is the effect of urine alkalinization on drug absorption/elimination? What will be the effect for acidic urine? Name 2 agents used to make urine acidic/basic. Weak Acid (pKa = 6.0) Weak Base (pKa = 7.0) !! HA A -NH,= -NH3 3 (1) Normal urine, pH= 6.0 Basic urine, pH= 8.0 2) 4) HA = A -NH, -NH3

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