Choose the most correct sentence according to AP and grammar rules for print journalism. 

 a) The safety and efficacy of the drug for the overwhelming majority of patients, as important as they are to all of us, is likely to be overshadowed by isolated adverse reactions. 

b) It is against the principals of the board to draw on the principle of its endowment even when the principal reason for doing so was altruistic.

c) The company aims to create visually appealing, user-friendly documentation that will help customers get the most out of their equipment, he said.

d) The Congressional Budget Office official said the study proves the need to forego frivolous purchases in uncertain economic times