consider the below synthetic route of (tafenoquine), and with consideration of 13 principles of green chemistry.

Q: identify two instances of reaction conditions which are undesirable for further process development.

Meo NH xylene MeO H2SO. (65%) Me OEI A (87%) Me Me OH Meo Meo Meo POCIE A (86.4%) Nao Me SO2Cl2 MeOH, A (92.6%) (81.2%) Me CI Me OMe Me CI Meo HNO3 + H2SO4 24 Me KOH, DMSO 1000 107 27 Ne One NH, H2O Pdre EIOH (91.3%) 22 24 Me NH 14 BHDMI NH4H20 EIOHA, 7h FC ADH NA Compound 14