Consider the scale-up of a stirred bioreactor from 5 L to 5 000 L. The small-scale bioreactor has a height-to-diameter ratio of 2.5. The scale-up is based on the following: the ratio of the impeller diameter to the tank diameter is 1:3 and the agitator speed is 400 rev/min. Calculate the size of the large bioreactor, impeller diameter and speed for each of the following cases: 1. constant impeller tip speed 2. constant Reynolds number