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Could you explain the principles of protein folding kinetics and thermodynamics, and their implications in protein misfolding diseases?

Could you explain the principles of protein folding kinetics and thermodynamics, and their implications in protein misfolding diseases? 

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Protein folding is a complicated procedure by which a protein chain thats to begin with unstructured unfolded assumes its functional 3dimensional folded shape This process is ruled via both thermodyna... blur-text-image

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