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Makers of generic drugs must show that they do not differ significantly from the "reference" drugs that they imitate. One aspect in which drugs might differ is their extent of absorption in the blood. Table below gives data taken from 20 healthy nonsmoking male subjects for one pair of drugs. This is a matched pairs design. Numbers 1 to 20 were assigned at random to the subjects. Subjects 1 to 10 received the generic drug first, followed by the reference drug. Subjects 11 to 20 received the reference drug first, followed by the generic drug. In all cases, a washout period separated the two drugs so that the first had disappeared from the blood before the subject took the second. By randomizing the order, we eliminate the order in which the drugs were administered from being confounded with the difference in the absorption in the blood. Do the drugs differ significantly in the amount absorbed in the blood?

ABSORPTION UTENT FOR TWO VERSIONS OF A DRUG SUBJECT REFERENCE GENERIC DRUG DRUG 15 4108 1755 3 2526 1138 9 2779 1613 13 3852 2254 12 1833 1310 8 2463 2120 18 2059 1851 20 1709 1878 17 1829 1682 2 2594 2613 4 2344 2783 16 1864 2302 6 1022 1284 10 2256 3052 5 938 1287 7 1339 1930 14 1262 1964 11 1438 2549 1 1735 3340 19 1020 3050