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create a Simulink model from this matlab code Show the results and model Step 1 : Model Initialization Create a new Simulink model. Add a
create a Simulink model from this matlab code Show the results and model Step : Model Initialization
Create a new Simulink model.
Add a Voltage Source block to represent the stimulus current Istim You can find this block under the Sources library in Simulink.
Add a Sum block to sum the ionic currents. You can find this block under the Math Operations library in Simulink.
Add a Scope block to visualize the membrane potential V and gating variables m n h You can find this block under the Sinks library in Simulink.
Step : Parameter Setup
Set the parameters of the HodgkinHuxley Neuron block to match the equations and parameters of the HodgkinHuxley model. This includes setting the membrane capacitance Cm maximum conductances gNa gK gL Nernst potentials ENa EK EL and rate constants alpha and beta
Step : Implementing the HodgkinHuxley Equations
Use a MATLAB Function block to implement the HodgkinHuxley equations.
Already included in the code Create a MATLAB function that calculates the membrane potential V and gating variable derivatives dmdt dndt dhdt based on the current membrane potential and gating variable values.
Use the MATLAB function to calculate the derivatives in the MATLAB Function block.
Step : Connecting Blocks
Connect the output of the MATLAB Function block to the input of the Scope block to visualize the simulation results.
Connect the output of the Voltage Source block to the input of the Sum block, and connect the output of the Sum block to the input of the MATLAB Function block.
Step : Simulation and Analysis
Run the simulation and observe the membrane potential and gating variable dynamics over time.
Analyze the behavior of the neuron in response to different stimulus currents and parameter values. Sample inputs
V ; Membrane potential mV
m ; Gating variable m
n ; Gating variable n
h ; Gating variable h
Istim ; Stimulus current uAcm
Cm ; Membrane capacitance uFcm
gNa ; Maximum sodium conductance mScm
gK ; Maximum potassium conductance mScm
gL ; Leak conductance mScm
ENa ; Sodium Nernst potential mV
EK ; Potassium Nernst potential mV
EL ; Leak Nernst potential mV
Call the function
dV dm dn dh hodgkinhuxleymodelV m n h Istim, Cm gNa, gK gL ENa, EK EL;
function dV dm dn dh hodgkinhuxleymodelV m n h Istim, Cm gNa, gK gL ENa, EK EL
Constants
~; Resting membrane potential mV
Sodium channel kinetics
alpham VexpV;
betam expV;
alphah expV;
betah expV;
Potassium channel kinetics
alphan VexpV;
betan expV;
Membrane currents
INa gNamhVENa;
IK gKnVEK;
IL gLVEL;
Membrane potential derivative
dV Istim INa IK IL Cm;
Gating variable derivatives
dm alphamm betamm;
dn alphann betann;
dh alphahh betahh;
end
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