decreased blood insulin C leads to upregulation of Glut4 transporters on muscle and fat cells treatment of a patient with beta blockers for an C extended period of time leads to downregulation of 1 beta receptors on muscle and fat cells decreased blood epinephrine leads to downregulation of Glut4 transporters on muscle and fat cells increased blood epinephrine leads to upregulation of 1 beta receptors on muscle and fat cells increased blood insulin leads to drug-induced upregulation of beta receptors on muscle and fat cells