Department of Chemical and Biological Engineering Dpartement de gnie chimique et biologique CHG4381 - Biochemical Engineering (3 credits) Fall 2016 Instructor Email Phone Office Office hours Dr. Kathlyn Kirkwood Kathlyn.Kirkwood@uOttawa.ca 562-5800 ext. 6097 CBY A406 Tuesdays, 1:30pm - 3:30pm (or by appointment) 1 - COURSE DESCRIPTION Elements of applied microbiology: taxonomy, morphology of micro-organisms, cell composition and metabolism, growth kinetics and product formation. Application of chemical engineering principles to the analysis of industrial fermentation processes. Bioreactor design and downstream processing. Industrial applications of bioprocesses: food processing, pharmaceuticals, conversion of waste materials to useful products. 2 - COURSE OBJECTIVE Biochemical Engineering involves the application of Chemical Engineering principles and approaches to bioprocesses, which employ biocatalysts such as cells and enzymes to produce novel bioproducts, bulk chemicals and potentially platform chemicals to satisfy the ever growing demands of industry, agriculture, environment, health-care, energy, etc. In this course you will learn the fundamentals of biochemical engineering. This involves understanding of microbial growth kinetics, medium formulation, batch and continuous bioreactor design, aeration, sterilization, product recovery and purification. 3 - PREREQUISITES Prerequisite: 81 university credits including CHG3111, CHG3127. CHG4381 1/8 4 - LECTURE SCHEDULE Lectures: Laboratory: Tutorials: Monday, 4:00-5:30 pm (CBY B205) Wednesday, 2:30-4:00 (CBY B205) N/A Monday, 8:30-10:00 (FTX 147A) 5-TEACHING ASSISTANTS Taisa Stumpf (tdasi041@uottawa.ca) Office hours: Fridays, 10am - 11am, location to be determined Zeqing Bao (zbao096@uottawa.ca) Office hours: Wednesdays, 10am - 11am, location to be determined 6 - TEXTBOOK The textbook is strongly recommended and will be used for general study, class preparation, and problem sets. Textbook: Bioprocess Engineering: Basic Concepts, 2nd Ed. by Shuler, M.L. and F. Kargi., Prentice Hall PTR, NJ 7 - ADDITIONAL READING A course pack of the lecture notes is available for purchase at the DocuCentre in UCU. Additional handouts may be posted in Blackboard Learn. Project-related research and reading will be required. 8 - TUTORIALS The course includes weekly DGD sessions to allow students to work on practice problems and on a group design project. Students will be required to submit work at the end of most tutorials. There will also be short quizzes in selected tutorials. Some tutorial work may be done online (e.g. using Socrative). Advance notice will be given if a web-connected device is required. CHG4381 2/8 9 - ASSIGNMENTS Assigned problems are for the student's benefit and carry no grade. The solution to selected problems will be posted. 10 - EXAMS/LABORATORY and/or PROJECT REPORTS There will be one midterm and one final exam in this course. The midterm is tentatively scheduled for Wednesday, October 19th. The University will release the date and time of the final examination sometime during the semester. All examinations are closed book. Quizzes to be conducted during selected tutorials will be closed book with no extra reference material allowed. There will be one group design project. The project work is mandatory - missing elements of this course component without a valid, documented reason (medical or family emergency) will result in an EIN for the course. Electronic copies of reports are to be submitted via the course website in Blackboard Learn by 16:00 on the due date. In addition, the hard copy of the report, including a signed form attesting that the work conforms to the rules of academic integrity at the University of Ottawa, must be submitted to the course assignment box by 16:00 on the due date. Turnitin will be used as part of the assessment of the reports. More details on the project will be provided during the term. 11 - ONLINE LECTURE NOTES The course pack will not be provided electronically. Additional course slides and material may be posted on Blackboard Learn at the discretion of the professor. 12 - GRADING SCHEME Tutorials (attendance, participation, quizzes) Group Project Midterm exam Final exam 5% 20% 25% 50% 13 - PASSING GRADE The passing grade for this course is 55% (D+). Students must also achieve a passing grade (D+ or higher) in the weighted average of their midterm and final exams (as per the grading scheme above) in order to pass the course. CHG4381 3/8 14 - CLASSROOM ETIQUETTE Class attendance is mandatory, including tutorials. As per academic regulations, students who do not attend 80% of the class will not be allowed to write the final examination. Cell-phones should be turned to silent. Laptop computers, tablets and similar devices should be closed. 15 - REMINDERS All components of the course (i.e., laboratory reports, assignments, project reports, etc.) must be fulfilled; otherwise students may receive an EIN as a final mark (equivalent to an F). This is also valid for a student who is taking the course for the second time. Information on academic fraud can be found at this link: http://www.engineering.uottawa.ca/downloads/pdf/FacultyRegulationsEnglish2008.pdf Students are to become familiar with the Faculty of Engineering rules and regulations; you may refer to them if you happen to miss an exam. These are within the University of Ottawa's regulations sections 9.4, 9.5, 9.6, 14.2 and 14.3, which define conduct during an examination, academic fraud, the sanctions and the decision and appeal processes: http://web5.uottawa.ca/admingov/regulations.html. Students are to become familiarize themselves with the University of Ottawa's policy on plagiarism (http://www.uottawa.ca/plagiarism.pdf and http://web5.uottawa.ca/mcssmc/academicintegrity/home.php). This policy will be strictly enforced in this course. Important dates and deadlines for the academic year can be found at the following link: http://www.registrar.uottawa.ca/Default.aspx?tabid=2671. Several resources from the faculty of engineering can be found at the following link: http://www.engineering.uottawa.ca/en/undergraduate/current_students/ Library resources for chemical engineers can be found at the following link: http://uottawa.ca.libguides.com/ChemicalEngineering-en If necessary, the instructor will contact students through their official University of Ottawa's e-mail address (username@uottawa.ca). If you are using a personal e-mail address, please go to the university mail management web site to set a forwarding address (https://web.uottawa.ca/cgi-bin/mailadmin/main.pl). You are responsible for ensuring you are receiving official course information in an efficient and timely manner. CHG4381 4/8 16 - TOPICS AND TENTATIVE SCHEDULE Date Topic Sept 7 Sept 12 Course overview Introduction Introduction Sept 14 Sept 19 Sept 21 Sept 26 Sept 28 Oct 3 Oct 5 Oct 10 Oct 12 Oct 17 Oct 19 Oct 24/26 Oct 31 Nov 2 Nov 7 Nov 9 Nov 14 Nov 16 Nov 21 Nov 23 Nov 28 Nov 30 Dec 5 Biological basics Biological basics Enzymes and enzyme reactions Enzymes and enzyme reactions Enzymes and enzyme reactions Whole cell processes Whole cell processes Thanksgiving (no class) Whole cell processes Whole cell processes MIDTERM EXAM Reading Week (no classes) Ideal chemostat Ideal chemostat Bioreactors Bioreactors Guest lecture: Dr. Jon Van Hamme, TRU Bioreactors Sterilization systems Sterilization systems Guest lecture: Dr. Rob Delatolla, uOttawa CVG Product recovery Bioprocess analysis Dec 7 Dec Review FINAL EXAM Chapters / reading 1 Turton: Appendix B.8 (coursepack) Heinzle: Citric acid (coursepack) 2 3.1-3.4 Lotfabad: Kinetics (coursepack) 6.1-6.3 Gomez-Flores: Clostridium (coursepack) 6.4 9.1-9.4, 10.2 9.1-9.4, 10.2 10.4 Fujikawa: Aspergillus (coursepack) 11 Tolan: Iogen (coursepack) Martens: Vitamin B12 (coursepack) 17 - OTHER INFORMATION The University of Ottawa provides, upon request, appropriate academic adjustments for students who have learning disabilities, health, psychiatric or physical conditions. For more information, please contact Access Service (http://www.sass.uottawa.ca/access/). CHG4381 5/8 18 - GRADUATE ATTRIBUTES ASSESSMENT CEAB Graduate Attribute: indicate with I* (\"introductory\") or A (\"advanced\") to indicate level of expected achievement 1 A 2 A 3 A 4 5 6 7 8 9 10 11 12 A * I: indicates students are working at a basic level, working with foundational elements, techniques or methodologies of the learning outcome A: indicates students are learning how to perform the attribute as written at a level that is expected of someone who is completing their degree Attribute Assessment Tools Identify your method for evaluating each attribute included in the table above, using the following nomenclature for your evaluation method and providing a brief description below E: Test/Quiz/Exam RI: Written Report, Individual RG: Written Report, Group PI: Project, Individual PG: Project, Group OI: Oral Presentation, Individual OG: Oral Presentation, Group AI: Assignment, Individual AG: Assignment, Group L: Lab Notebook/Portfolio SP: Self or Peer Evaluation O: Other (please specify) CEAB Attribute Number Assessment Tool Description of Assessment Tool 1 E, PG Indicator 1.2. Demonstrates basic knowledge/understanding of biological principles Indicator 1.3. Applies biological principles to bioprocess engineering 2 E, PG Indicator 2.1 and 2.2. Selects and applies appropriate equations to solve diverse biochemical engineering problems Indicator 2.3. Evaluates and selects appropriate models for bioreactor design Indicator 2.4. Uses advanced knowledge of unit operations, chemical engineering principles and biological principles to select bioprocess operations 3 E, PG Indicator 3.1. Conducts literature review to determine the specific subject of course design project and relevant parameters required for the design Indictor 3.2. Determines a series of simulations / computations required for bioreactor design 4 PG Indicator 4.1. Conceptual design of a biochemical process for the production of a target product Indicator 4.2. Selects relevant process variables and evaluates possible outcomes by simulating different options of a biochemical process for the production of a target product, using models and experimental / industrial data from literature Indicator 4.3 and 4.4. Uses results of simulation and literature review to select and propose optimal design; design of a key unit operation in a biochemical process CHG4381 6/8 Graduate Attribute and Indicator Cross Reference . 1 A knowledge base for engineering: Demonstrated competence in university level mathematics, natural sciences, engineering fundamentals, and specialized engineering knowledge appropriate to the program. . 2 Problem analysis: An ability to use appropriate knowledge and skills to identify, formulate, analyze, and solve complex engineering problems in order to reach substantiated conclusions. . 3 Investigation: An ability to conduct investigations of complex problems by methods that include appropriate experiments, analysis and interpretation of data, and synthesis of information in order to reach valid conclusions. . 4 Design: An ability to design solutions for complex, open-ended engineering problems and to design systems, components or processes that meet specified needs with appropriate attention to health and safety risks, applicable standards, and economic, environmental, cultural and societal considerations. . 5 Use of engineering tools: An ability to create, select, apply, adapt, and extend appropriate techniques, resources, and modern engineering tools to a range of engineering activities, from simple to complex, with an understanding of the associated limitations. . . . . 6 Individual and team work: An ability to work effectively as a member and leader in teams, preferably in a multi-disciplinary setting. 7 Communication skills: An ability to communicate complex engineering concepts within the profession and with society at large. Such ability includes reading, writing, speaking and listening, and the ability to comprehend and write effective reports and design documentation, and to give and effectively respond to clear instructions. . 8 Professionalism: An understanding of the roles and responsibilities of the professional engineer in society, especially the primary role of protection of the public and the public interest. . 9 Impact of engineering on society and the environment: An ability to analyze social and environmental aspects of engineering activities. Such ability includes an understanding of the interactions that engineering has with the economic, social, health, safety, legal, and cultural aspects of society, the uncertainties in the prediction of such interactions; and the concepts of sustainable design and development and environmental stewardship. . 10 . 11 Economics and project management: An ability to appropriately incorporate economics and business practices including project, risk, and change management into the practice of engineering and to understand their limitations. . 12 Life-long learning: An ability to identify and to address their own educational needs in a changing world in ways sufficient to maintain their competence and to allow them to contribute to the advancement of knowledge. Ethics and equity: An ability to apply professional ethics, accountability, and equity. 19-PERSONAL ETHICS AGREEMENT CONCERNING UNIVERSITY ASSIGNMENTS See following pages CHG4381 7/8 Personal Ethics Agreement Concerning University Assignments Group Assignment We submit this assignment and attest that we have applied all the appropriate rules of quotation and referencing in use at the University of Ottawa. We also confirm that we have taken knowledge of and respected the Beware of Plagiarism! brochure found on the uOttawa website. We attest that this work conforms to the rules on academic integrity of the University of Ottawa. We understand that this assignment will not be accepted or graded if it is submitted without the signatures of all group members. _______________________________ Name, Capital letters _________________ Student number _______________________________ Signature _________________ Date _______________________________ Name, Capital letters _________________ Student number _______________________________ Signature _________________ Date _______________________________ Name, Capital letters _________________ Student number _______________________________ Signature _________________ Date _______________________________ Name, Capital letters _________________ Student number _______________________________ Signature _________________ Date _______________________________ Name, Capital letters _________________ Student number _______________________________ Signature _________________ Date CHG4381 8/8