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Determine an estimate of the blood flow rate needed to sustain a total of 750,000 islets. Each islet can be assumed to be 150 m

Determine an estimate of the blood flow rate needed to sustain a total of 750,000 islets. Each islet can be assumed to be 150 m in diameter.

Given:

pO2(avg) = 68mmHg

basal oxygen consumption rate = 25.9 M s1

half-thickness () of the islet layer = 200 microns

cell volume fraction () = 0.15

DT = 1.67 105 cm2 s1

membrane oxygen permeability (Pm) = 4 103 cm s1

pO2(x=) = 19.2 mmHg

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