Diet and lifestyle influence colorectal cancer recurrence The role of dietary supplement use in colorectal cancer recurrence remains controversial In this study, we examined the association between dietary supplement use and colorectal cancer recurrence Colorectal cancer cases were recruited between 1995 and 2002 and followed until 2008 Cancers with with a diameter of 1 cm and or (tubulo)villous histology and or with high grade dysplasia and or 3 adenomas detected at the same colonic examination were considered as recurrent cancers Results were adjusted for age, sex, educational level and number of colonoscopies during follow up The following 2x2 tables are hypothetical results based on the scenario above Use these tables to answer the next set of questions For the purposes of this assignment, consider dietary supplement use as exposed and non use of the supplement as unexposed Females (Stratum 1) Colorectal Cancer Recurrence No Recurrence Supplement Use Yes 160 240 No 40 360 Males (Stratum 2) Colorectal Cancer Recurrence No Recurrence Supplement Use Yes 40 560 No 10 590 (4 points) Calculate the risk ratio and 95 confidence intervals for colorectal cancer recurrence among those who used the dietary supplement compared to those who did not use the dietary supplement for males and females separately Round your answers to the nearest tenth and present them in interval notation, like this RR X X (X X, X X) (2 points) Are the RRs that you calculated in the previous problem, statistically significant How did you determine this (3 points) Calculate the crude RR and 95 confidence interval for colorectal cancer recurrence among those who used the dietary supplement compared to those who did not use the dietary supplement Round your answer to the nearest tenth and present them in interval notation, like this RR X X (X X, X X) Hint you will need to combine the 2x2 tables above in order to do this (2 points) Is the crude RR that you calculated in the previous problem, statistically significant How did you determine this (2 points) Based on your previous responses, does gender modify or confound the observed association How did you determine this (2 points) In this instance, what study result(s) should be reported

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Diet and lifestyle influence colorectal cancer recurrence. The role of dietary supplement use in colorectal cancer recurrence remains controversial. In this study, we examined the

Diet and lifestyle influence colorectal cancer recurrence. The role of dietary supplement use in colorectal cancer recurrence remains controversial. In this study, we examined the association between dietary supplement use and colorectal cancer recurrence. Colorectal cancer cases were recruited between 1995 and 2002 and followed until 2008. Cancers with with a diameter of 1 cm and/or (tubulo)villous histology and/or with high grade dysplasia and/or 3 adenomas detected at the same colonic examination were considered as recurrent cancers. Results were adjusted for age, sex, educational level and number of colonoscopies during follow-up.

The following 2x2 tables are hypothetical results based on the scenario above. Use these tables to answer the next set of questions. For the purposes of this assignment, consider dietary supplement use as exposed and non-use of the supplement as unexposed.

Females (Stratum 1)

		Colorectal Cancer Recurrence	No Recurrence
Supplement Use	Yes	160	240
Supplement Use	No	40	360

Males (Stratum 2)

		Colorectal Cancer Recurrence	No Recurrence
Supplement Use	Yes	40	560
Supplement Use	No	10	590

(4 points) Calculate the risk ratio and 95% confidence intervals for colorectal cancer recurrence among those who used the dietary supplement compared to those who did not use the dietary supplement for males and females separately. Round your answers to the nearest tenth and present them in interval notation, like this RR= X.X (X.X, X.X).

(2 points) Are the RRs that you calculated in the previous problem, statistically significant? How did you determine this?

(3 points) Calculate the crude RR and 95% confidence interval for colorectal cancer recurrence among those who used the dietary supplement compared to those who did not use the dietary supplement. Round your answer to the nearest tenth and present them in interval notation, like this RR= X.X (X.X, X.X).Hint: you will need to combine the 2x2 tables above in order to do this.