DRUG DESIGN PLEASE ANSWER WHAT IS INDICATED

The mechanism of action of quinolones includes an interaction in which a Mg2+ ion plays a important role in the union of the quinolone to the complex formed with DNA-gyrase, existing a electrostatic and/or covalent interaction between the Mg2+ ion and a quinolone molecule together with the phosphate groups and DNA bases. Draw the structure of the complex formed. make a schematic representation between the following quinolones and DNA gyrase.

Chelation occurs with metal ions such as: aluminum (III), magnesium (II), calcium (II), iron (II and III) and copper (II), originating complexes insoluble in water. How does this fact affect the way administer the drug? If taken orally along with antacids, what will the expected level be in plasma?

cido nalidxico ciprofloxacina