Dwayne Morrison is a 59-year-old man who came to a new provider at the family medicine clinic today with complaints of increasing shortness of breath. He points out that he first noticed some difficulty catching his breath at his job 3 years ago. He had been able to carry heavy loads up and down a flight of stairs daily for the last 35 years without any problem. However, his shortness of breath began to make this very difficult. Coincidently at that time, he accepted a managerial position at his company that significantly reduced his activity level. After taking this position, he no longer noticed any problems, but admits that he avoids activities that cause him to physically exert himself. He noticed significant shortness of breath again after he moved to Colorado from a lower elevation 2 months ago to be closer to his grandchildren. His shortness of breath is worst when he is outside playing with his grandchildren. He is hoping to get a good medication that will help relieve his shortness of breath because the gardening season is right around the corner and he enjoys this hobby. Dwayne Morrison also informed the physician that he has been smoking 5-6 cigarettes per day since his early college days and has not given it up yet. The physician also noticed that Mr. Morrison has decreased exercise tolerance, chest tightness (probably due to cough), and his lungs have a wheezing sound. Further clinical investigation revealed inflammation in the bronchial region.

1. Which eicosanoid is majorly responsible for inflammation associated with this disease state? Describe its role as well as the biochemical pathway linked with the synthesis of this eicosanoid?