estion: Which of the following are the responsibilities of the principal investigator $($PI$)$ of a study?

A$)$ Ensure that U$-$M$\text{'}$s federalwide assurance is up$-$to$-$date with the federal Office of Human Research Protections.

B$)$ Ensure that all research activities have IRB approval and other approvals required by the institution before human participants are involved in the research.

C$)$ Ensure that all associates, colleagues, and employees assisting in the conduct of the study are informed about their obligations and trained to carry out their duties.

D$)$ Ensure the confidentiality and security of all research information obtained from and about the human participants.

E$)$ Become familiar with ethical and regulatory requirements for human research.