explain the role of capital investment analysis for the company C Chairman of Amgen Inc. (AMGN) (a biotech company): "You cannot really run the numbers, do net present value calculations, because the uncertainties are really gigantic... You decide on a project you want to run, and then you run the numbers [as a reality check on your assumptions]. Success in a business like this is much more dependent on tracking rather than on predicting, much more dependent on seeing results over time, tracking and adjusting and readjusting, much more dynamic, much more flexible."