Figure 1. Scatter plot comparing the rates of spontaneous mutation resulting in resistance (x-axis) versus th number of years for antibiotic resistance to render that antibiotic ineffective (y-axis). Use the graph to answer th following questions. For a full color version after class, consult the pdf on Moodle. (Image credit: Sommer et al., 2017 Nat Rev Microbiol doi:10.1038/nrmicro.2017.75) 1. Compare Linezolid (far left) to Ampicillin (far right). Based solely on the spontaneous mutation rate, which antibiotic would you expect mutation-based resistance to appear later? Linezolid, because the amount of time to acquire resistance is less than 2.5 years b. Linezolid, because the spontaneous mutation rate is lower than ampicillin Ampicillin, because the spontaneous mutation rate is lower than linezolid Ampicillin, because the amount of time to acquire resistance is more than 5 years e. None of the above, the graph does not provide enough data to answer this question c. Time to acquire resistance (years) 7.5 5.0- 2.5 0.0- -2.5- 10-00 10" 10 10 10 10 Spontaneous resistance mutation (rate per cell per generation) Streptomycin (aminoglycoside) Ciprofloxacin (quinolone) Ampicillin (-lactam) Prontosil (sulfadrug) Chloramphenicol (phenicol) Erythromycin (macrolide) Chlortetracycline (tetracycline) Rifampicin (rifamycin) Linezolid (oxazolidinone)