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The cyclization reaction shown below involves two sequential condensation reactions, and can be catalyzed by either a strong acid or a strong base. a.

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The cyclization reaction shown below involves two sequential condensation reactions, and can be catalyzed by either a strong acid or a strong base. a. Draw the neutral intermediate that would form after the first condensation but before the second condensation in each mechanistic pathway option. acid or R2 base (cat.) aldol condensation NH2 R3 condensation imine R R2 HO N R3 2 HO HO b. Draw the missing starting material for the synthesis of SN-38, using the same cyclization reaction as shown above. HO acid or base (cat.) HO (similar reaction as above) HO SN-38 (cancer treatment)

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Solutions Step 1 a The starting materials for the basecatalyzed cyclization reaction of cabotegravir are 124Dichlorophenyl4ethyl13dihydro2Hbenzimidazol2one Ethyl cyanoacetate Sodium hydride NaH Dimeth... blur-text-image

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