For this exercise assume that the pharmacokinetic data reported in the document reflect the population mean () and population standard deviation (?).

7. What is the mean and standard deviation for Cmax (ng/ml) and AUC (ng-hr/ml) following multiple dose administration of VEKLURY (100 mg, IV dose) to healthy adults? (note: AUC tau refers to the steady state AUC following multiple dosing - use this value in the assignment).Table 12 Multiple Dose PK Parameters of Remdesivir and Metabolites (GS-441524 and GS- 704277) Following IV Administration of VEKLURY 100 mg to Healthy Adults Parameter Remdesivir GS-441524 GS-704277 Mean (CV%) Cmax (nanogram per mL) 2229 (19.2) 145 (19.3) 246 (33.9) AUCtau 1585 (16.6) 2229 (18.4) 462 (31.4) (nanogram.h per mL) Ctrough ND 69.2 (18.2) ND (nanogram per mL) CV=Coefficient of Variation; ND=Not detectable (at 24 hours post-dose) a. Remdesivir administered as a 30-minute IV infusion (Study GS-US-399-5505)