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For two-sample comparisons, say, smokers vs. non-smokers in FEV, can one simply determine if there is a significant difference in FEV between smokers and non-smokers

For two-sample comparisons, say, smokers vs. non-smokers in FEV, can one simply determine if there is a significant difference in FEV between smokers and non-smokers based on whether the two 95% CIs of mean FEV (one for mean FEV of smokers and the other for mean FEV of non-smokers) are overlapping or not?

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