Given:

i) Calculate total AUC from the oral dose (AUC0-,PO) by trapezoid method (fill in the blank cells to calculate the area of each trapezoid from time = 0 to tlast and then calculate the extrapolated AUC from tlast to infinity and add up all the resulting numbers to get total AUC). Round your final answer to the nearest hundredth. AUC_0-,PO =______mg.hr/L

ii) Calculate CL of drug X in KM using total AUC value from IV bolus dose calculated using trapezoid and equation method. You can use Excel file to calculate AUC from trapezoid method. Round your final answer to the nearest tenth. Cl =_____L/h

iii) Calculate bioavailability (F) for PO dose. Round your final answer to the nearest tenth. F = _______.

iv) Calculate the fe and fm of drug X in KM. Express your answers as percentages and round your final answer to the nearest integer.( f_e = ______%, fm= ______%)

Time (hr) CPO (mg/L) AUCt1-t2 (mg.hr/L) 0 0 0.20 0.54 0.44 0.75 1.05 0.28 1 1.17 1.25 1.2 0.90 2 1.2 2.16 4 0.96 3.12 8 0.6 1.08 10 0.48 AUC0-00,PO = Time (hr) CPO (mg/L) AUCt1-t2 (mg.hr/L) 0 0 0.20 0.54 0.44 0.75 1.05 0.28 1 1.17 1.25 1.2 0.90 2 1.2 2.16 4 0.96 3.12 8 0.6 1.08 10 0.48 AUC0-00,PO =