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Hello, I am having difficulty solving the following question: A new medicine was given to a sample of 100 patients. Of the total, 73 reacted

Hello, I am having difficulty solving the following question:

"A new medicine was given to a sample of 100 patients. Of the total, 73 reacted favorably, 6 reacted unfavorably, and 21 were unaffected. If the drug is given to Mr and Mrs Smith, their son and their daughter, what is the probability that all four will react favorably. Assume independence."

Thank you for your help.

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