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Hereditary hemochromatosis (HH) is a recessively inherited genetic disorder resulting from mutations in the HFE gene. There are several possible mutations of different degrees of

Hereditary hemochromatosis (HH) is a recessively inherited genetic disorder resulting from mutations in the HFE gene. There are several possible mutations of different degrees of importance but the disease expresses itself when the C282Y allele type is involved in this gene. The condition HH is particularly serious if two such alleles are inherited. It is thought to be particularly prevalent in males with Northern European ancestry. A blood analysis was performed on 1000 Norwegian males. The results showed that 69 of those sampled carried at least one C282Y allele.

The proportion of this HFE C282Y allele in the general southern European population (eg Italy) is known to be 3.8%. Perform a test of significance at 5% to determine if the proportion of HFE gene is greater in the Northern European male population. Show all steps clearly.

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