How can competitive and noncompetitive inhibition be distinguished in terms of the Lineweaver-Burk plot? The slope and y-intercept of the Lineweaver-Burk plot change with both noncompetitive and competitive inhibition. The slope and y-intercept of the Lineweaver-Burk plot change with competitive inhibition, whereas only the slope changes with noncompetitive inhibition. The slope and y-intercept of the Lineweaver-Burk plot change with noncompetitive inhibition, whereas only the y-intercept changes with competitive inhibition. The slope and y-intercept of the Lineweaver-Burk plot change with noncompetitive inhibition, whereas only the slope changes with competitive inhibition