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How do cytokine storms arise, and what are the underlying immunological mechanisms that lead to their pathogenicity in severe inflammatory conditions such as sepsis or

How do cytokine storms arise, and what are the underlying immunological mechanisms that lead to their pathogenicity in severe inflammatory conditions such as sepsis or cytokine release syndrome? 

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Cytokine storms occur when the immune system overreacts to an infection or other stimulus leading to an excessive release of proinflammatory cytokines ... blur-text-image

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