How Protein Kiase A Is Activated? Activated Protein Kiase A Has Diverse Cellular Functions Justify The Statement With Proper Examples. What Is The Physiological Significant Of ER Associated Protein Degradations (ERADD What Will Happen To The Cell If You Blo0ck ERAD Using A Specific Inhibitor? Why Termination Of A Cell Signaling Event Is Important? Explain

 

 

 

Sem. Cell Biology (LS3201) 1.12.2015 Full Marks: 50 SECTION A (Answer All Questions) Time: 3 hours 1. How Protein Kiase A is activated? Activated Protein Kinase A has diverse cellular functions- Justify the statement with proper examples 243 What is the physiological significance of ER associated protein degradation (ERADY What will happen to the cell if you block ERAD using a specific inhibitor? * 3+2 Why termination of a cell signaling event is important explain with two examples how GPCR signaling is terminated. SECTION B: Answer any five 2+3 What is actin filaments treadmilling? What would be the consequence for actin filament assembly/disassembly if a mutation prevented actin's ability to bind ATP? What would be the consequence if a mutation prevented actin's ability to hydrolyze ATP Predict the effect on a cell's actin cytoskeleton if function-blocking antibody against cofilin was microinjected into cells. How can you prepare one very stable actin filament in-vitro artificially? 2+1+1+1+2-7 How cellular components have bidirectional movement on microtubules? Is it possible for certain cellular components to move on both directions along actin filament What is MTOC? 2+2+1+2=7 How it play important role during cell division? Kinesin has two globular domains and each can bind to -tubulin a & -tubulin dimer has length 8-nm. What is the length of the steps for kinesin? Js this a continuous speed or does kinesin take discrete steps? How does the interaction of myosin and actin affected by ATP binding? What will the effect of a non-hydrolyzable analogue of ATP on muscle contraction? 1+2+1+2+1=7 And why? What is stem cell self renewal? How self renewal is regulated? What is neurotrophin, explain