I don't even understand this gist. Can anyone explain in an easy way?

3. Excessive and improper use of antibiotics is contributing to the resistance of many diseases to existing antibiotics. Consider a regulatory program in the United States that would monitor antibiotic prescribing by physicians. Analysts estimate the direct costs of enforcement to be $40 million, the time costs to doctors and health professionals to be $220 million, and the convenience costs to patients to be $180 million (all annually). The annual benefits of the program are estimated to be $350 million in avoided resistance costs in the United States, $70 million in health benefits in the United States from better compliance with prescriptions, and $280 million in avoided resistance costs in the rest of the world.

1) Does the program have positive net benefits from the national perspective?

1-1) If not, what fraction of benefits accruing in the rest of the world would have to be counted for the program to have positive net benefits?