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I would like to know how to solve the problems presented by using Matlab. Upvoting for the correct answer. Thank you! Project 3 A Blood-Brain
I would like to know how to solve the problems presented by using Matlab. Upvoting for the correct answer. Thank you!
Project 3 A Blood-Brain Pharmacokinetic Model Pharmacokinetics is the study of the time variation of drug and metabolite levels in the various fluids and tissues of the body. The discipline frequently makes use of compartment models to interpret data. In this problem, we consider a simple blood-brain compartment model (Figure 3.P.9), Compartment 1 = Blood, Compartment 2 = Brain, that could be used to help estimate dosage strengths of an orally administered antidepressant drug. The rate at which the drug moves from compartment i to compartment j is denoted by the rate constant k; while the rate at which the drug is removed from the blood is represented by the rate constant K. A pharmaceutical company must weigh many factors in determining drug dosage pa- rameters; of particular importance are dosage strengths that will provide flexibility to a physician in determining individual dosage regimens to conveniently maintain concentra- tion levels at effective therapeutic values while minimizing local irritation and other adverse side effects. TO k21 Input dit) Blood *1, V1,01 k12 Brain x2, V2,02 K FIGURE 3.P.9 A two-compartment model for periodic drug dosages. Assuming that the drug is rapidly absorbed into the bloodstream following its introduction into the stomach, a mathematical idealization for the dosage regimen is that of a periodic square wave ROStep by Step Solution
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