In 1982, a brewers' trade association and various beer producers and importers (a subset of the appellees in the instant litigation) filed suit in the United States District Court for the District of Connecticut, challenging the 1981 statute as

328

*328unconstitutional under the Commerce Clause. The District Court, relying primarily on this Court's decision inJoseph E. Seagram & Sons, Inc.v.Hostetter,384 U. S. 35 (1966),upheld the 1981 law.United States Brewers Assn., Inc.v.Healy,532 F. Supp., at 1325-1326. The Court of Appeals, however, reversed. It held that the 1981 Connecticut statute was facially invalid under the Commerce Clause because it had the practical effect of prohibiting out-of-state shippers from selling beer in any neighboring State in a given month at a price below what it had posted in Connecticut at the start of that month. The court explained: "Nothing in the Twenty-first Amendment permits Connecticut to set the minimum prices for the sale of beer in any other state, and well-established Commerce Clause principles prohibit the state from controlling the prices set for sales occurring wholly outside its territory."United States Brewers Assn., Inc.v.Healy,692 F. 2d 275, 282 (CA2 1982)(Healy I).This Court summarily affirmed. 464 U. S. 909 (1983).

Question 1

What else could we use instead of propranolol in thyrotoxicosis with

bronchial asthma?

Question 2

At what dose, and for how long, would steroid therapy give rise to

secondary adrenal insufficiency? For adrenal insufficiency due to longterm steroid use, when should we start to give a cortisone supplement?

How should we monitor these patients?

Question 3

What dose of Synacthen is equivalent to adrenocorticotrophic hormone

(ACTH)?

Question 4

I want to know the mechanism that causes anaemia in Addison's disease.

I am unable to find the real cause.

Question 5

What causes hypercalcaemia in Addison's disease?

Question 6

In the diagnosis of Cushing's disease using the high-dose dexamethasone suppression test, how can the exogenous steroid suppress

?

Question 7

Does alternate-day therapy with steroids decrease their efficacy

compared with daily therapy?

Question 8

Regarding the renin-angiotensin-aldosterone axis, it states that dietary

sodium excess suppresses renin secretion. Then why are we asking

hypertensives to restrict sodium intake? Also if we are using angiotensinconverting enzyme (ACE) inhibitors, the plasma renin activity increases

due to loss of feedback inhibition. Wouldn't that be counterproductive?

Question 9

How does a phaeochromocytoma give rise to Raynaud's phenomenon?

Question 10

How well do symptoms of hypercalcaemia correlate with serum calcium

levels. Can I ignore an asymptomatic patient with a serum calcium of

3.7 mmol/L but have to give treatment to a symptomatic patient who has

a serum calcium of 3.3 mmol/L?213018