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In a prospective cohort study conducted in western Europe, a rate ratio of 1.41 was reported for the association of any exposure to glyphosate (a

In a prospective cohort study conducted in western Europe, a rate ratio of 1.41 was reported for the association of any exposure to glyphosate (a broad-spectrum herbicide in Roundup, compared to no exposure to glyphosate) and incident cancer in adults. Twenty-six percent of cohort members were lost to follow-up over the course of the study. If participants with any glyphosate exposure who developed cancer were more likely to be lost to follow-up than were participants with no glyphosate exposure who developed cancer, the observed rate ratio of 1.41 would be (assuming no other source of bias and no confounding):

a.

an overestimate of the true association (upward bias).

b.

an underestimate of the true association (downward bias).

c.

the same as the true association (no bias).

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