In an RNA-seq experiment between normal vs tumor conditions, gene A has log2 (tumorormal) =2.5. This gene is 2 -fold down regulated. True False QUESTION 8 In an RNA-seq experiment between normal vs tumor conditions, gene B has log2 (tumorinormal) =0.95. This gene is 2 -fold up regulated. True False In an RNA-seq experiment between normal vs tumor conditions, gene C has (tumorinormal) =1.5 This gene is 2 -fold up regulated. True False QUESTION 10 Two microarray datasets measured in different laboratories using the same RNA starting material have a correlation coeificient r=0.8,r2=0.64. This means that: 80% of the variability in the gene expression in the 2 datasets can be explained by the agreement of the results between the 2 labs. 64% of the variability in the gene expression in the 2 datasets can be explained by the agreement of the results between the 2 labs. 20% can be explained by other factors such as error. Both a and c. Which one of the following is NOT a distance metric used in clustering algorithms? Euclidean distance. Manhattan distance. Pearson correlation coefficient. ANOVA QUESTION 12 If a gene is truly differentially expressed between 2 conditions and the statistical test reports this gene as not differentially expressed, this is: true positive false positive true negative false negative Alternative spliced transcripts can be detected by: microarrays RNA-seq both microarrays and RNA-seq statistical analysis QUESTION 14 Known transcripts abundance can be detected by: microarrays RNA-seq both microarrays and RNA-seq statistical analysis