In class, we talked about how the Unfolded Protein Response (UPR) is triggered in eukaryotic cells when protein production exceeds the cell's folding capabilities. a.) How does activation of the UPR alter gene expression in the cell? In what other ways might the cell change its behavior to aid in proper protein folding within the ER? b.) Briefly explain why it is important to monitor UPR activation when expressing a recombinant protein. c.) Given what you know about protein folding, what might be a common feature of misfolded proteins? How does the UPR pathway sense misfolded protein in the ER? d.) Briefly explain how alternative splicing is involved in mediating protein misfolding in the ER.