In June 2008, theJournal of the American Academy of Dermatologyreported on the use of an intermittent therapy for flare prevention and long-term disease control of eczema (red, inflamed, itchy skin). Eczema is a chronic skin disease that affects about 10% to 20% of infants and about 3% of adults and children in the United States. Researchers wanted to determine whether intermittent dosing with a specific topical inhibitor is effective in preventing eczema flare-ups in patients with stabilized eczema. Initially, 383 adults and children with moderate to severe eczema were treated with daily doses of the topical inhibitor. After 16 weeks, 197 were disease free and admitted into the maintenance phase of the study. These patients were randomized to a 3-times-weekly treatment with either the topical inhibitor or a placebo for 40 weeks. All tubes of ointments (topical inhibitor and placebo) were packaged in identical boxes and labeled "for investigational use only." Then the packages were sealed with tamper-proof seals and shipped. Neither the researchers nor the patients knew who received the topical inhibitor or who received the placebo. During the maintenance phase researchers tracked the number of flare-free days for each patient.