Answered step by step
Verified Expert Solution
Link Copied!

Question

1 Approved Answer

In most mammalian genomes, the dinucleotide CpG (that is, a C next to G on a single strand of DNA) is generally underrepresented relative to

In most mammalian genomes, the dinucleotide CpG (that is, a C next to G on a single strand of DNA) is generally underrepresented relative to expectation. If the overall genome frequency of cytosine and guanine is fC=0.3 and fG=0.3, at what frequency would you expect to find the CpG dinucleotide, assuming the genome is composed of bases in random order?

If you observed N CpGs out of a genome of length L bases, how might you determine whether the observed N is significantly underrepresented relative to expectation? Detail all steps you would take through to your final decision of being underrepresented or not.

Step by Step Solution

There are 3 Steps involved in it

Step: 1

blur-text-image

Get Instant Access to Expert-Tailored Solutions

See step-by-step solutions with expert insights and AI powered tools for academic success

Step: 2

blur-text-image

Step: 3

blur-text-image

Ace Your Homework with AI

Get the answers you need in no time with our AI-driven, step-by-step assistance

Get Started

Recommended Textbook for

Trigonometry

Authors: David M Kennedy, James Stewart, Lothar Redlin, Saleem Watson

2nd Edition

1285226089, 9781285226088

More Books

Students also viewed these Mathematics questions

Question

3. An initial value (anchoring).

Answered: 1 week ago

Question

4. Similarity (representativeness).

Answered: 1 week ago