In the study published by von Minckwitz, G et al (N Engl J Med 380:617-628, 2019: Which was the most important factor that the investigators compared between treatment groups, in order to determine whether the trial achieved its main objective? Question 8Answer The time that had elapsed before side effects were experienced How long it took until participants' tumours regrew, new tumours arose, or they died The proportion of patients who withdrew from the trial before it concluded The proportion of patients who developed brain metastases during the trial The proportion of patients who suffered drug-related toxicities The time that each participant survived for, after starting the trial