Answered step by step
Verified Expert Solution
Question
1 Approved Answer
Investigators were designing a randomized clinical trial to evaluate whether a new treatment reduces the risk of disease. They determined that their total sample size,
Investigators were designing a randomized clinical trial to evaluate whether a new treatment reduces the risk of disease. They determined that their total sample size, where half of the participants are assigned to treatment and half are assigned to placebo, provides 80% power to detect a relative risk of 0.7, assuming a signicance level of 0.05. A reviewer suggested that the researchers should design their trial to detect a relative risk of 0.9. How should the investigators adjust their sample size to detect a relative risk of 0.9 (instead of 0.7) without changing other aspects of their study design? Should the investigators increase their sample size, decrease their sample size, or keep the sample size the same? Briey explain your
Step by Step Solution
There are 3 Steps involved in it
Step: 1
Get Instant Access to Expert-Tailored Solutions
See step-by-step solutions with expert insights and AI powered tools for academic success
Step: 2
Step: 3
Ace Your Homework with AI
Get the answers you need in no time with our AI-driven, step-by-step assistance
Get Started