Iramdonly placebo-controlled study, 1026 healthy women 45 years of age or older were randomly divided into two groups. The women in group 1 received 100 mg of a drug every other day; the women in group 2 received a placebo every other day. The women were monitored for 10 years to determine if they experienced acardiovascular event (such as a heart attack

or stroke). 508 drug group 11 of them have heart attack while 518 placebo groups 17 have a heart attack

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