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J 1 Suppose a woman aged 53 years old has a serum-estradiol measurement of 13.5 pg/mL. Given an overall cancer prevalence of 2% and using

J 1

Suppose a woman aged 53 years old has a serum-estradiol measurement of 13.5 pg/mL. Given an overall cancer prevalence of 2% and using the cutpoint of 20 pg/mL to define a positive test, what is the probability that she does NOT have cancer?

Consider the alternate cutpoint of serum-estradiol of 10 pg/mL. Repeat parts a-d with the new cutpoint. Which classifier (20+ vs. 10+) has superior sensitivity, specificity, NPV, and PPV?

Suppose a woman aged 53 years old has a serum-estradiol measurement of 13.5 pg/mL. Given an overall cancer prevalence of 2% and using the cutpoint of 10 pg/mL, what is the probability that she does NOT have cancer?

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