let information be more than explanation

Question 1

Why are lipid-lowering drugs (statins) administered at bed time?

Question 2

What is the best statin now and what is your opinion about Crestor 10 mg

(rosuvastatin) and Lescol XL (fluvastatin sodium)?

Question 3

How long do statins take to achieve their maximum benefit?

Question 4

If, after 4 months of taking simvastatin (20 mg daily), a patient with

hyperlipidaemia and hypertension has an increased aspartate transferase

(AST) of up to 60 U/L, with a normal alanine transferase (ALT), what

action should I take?1953

Question 5

How long should the statins be continued once the lipid profile returns to

normal? Can we stop the statins once normal levels are attained and then

continue with diet modification?

Question 6

Are there any indications for routinely prescribing a statin (simvastatin, for

example) in hypertensive and/or diabetic patients as prophylactic therapy?

Question 7

What are the causes of vomiting and other gastrointestinal tract problems

in type 2 diabetes mellitus? What is the correct treatment for a patient

with nausea and vomiting, already taking hypoglycaemic agents and

antihypertensives?63

Question 8

In diabetic ketoacidosis there is an overall potassium deficit. Since insulin

promotes cellular potassium uptake, potassium should be given along

with insulin in the treatment of ketoacidosis since hypokalaemia could

potentially cause tachycardia. Why? I realise that hyperkalaemia can cause

problems since the concentration gradient and therefore the membrane

potential is reduced thus inhibiting proper function, but what is the

problem with hypokalaemia? Is it that the membrane potential and the

concentration gradient are too large? If so, how is this possible considering

that the body may have too little potassium to make the intracellular

concentration approach normal, so that although the extracellular

concentration is reduced, the intracellular concentration is also reduced?

Question 9

Can diabetes mellitus result in Horner's syndrome with no other

neurological deficit?

Question 10

Which drug is best recommended for a diabetic patient with rheumatoid

arthritis resistant to methotrexate, and requiring frequent pushes with

intramuscular depot preparations of methylprednisolone?