LTCM was wildly successful from 1994-1998, attracting more than $1 billion of investor capital with the promise of an arbitrage strategy that could take advantage of temporary changes in market behavior and, theoretically, reduce the risk level to zero. However, LTCM's highly leveraged trading strategies failed to pan out and it suffered monumental losses. The reverberations were felt across the financial landscape and nearly collapsed the global financial system in 1998. Ultimately, the U.S. government had to step in and arrange a bailout of LTCM by a consortium of Wall Street banks in order to prevent systemic contagion.16. Question 1Does long-term treatment with paracetamol (acetaminophen) 500 mg/day, as opposed to ibuprofen 600 mg/day, reduce the risk of renal toxicity in a young patient with osteoarthritis?2.How likely are these two treatments to cause renal toxicity? Question 17: In every case of severe osteoarthritis in India, total knee replacements are recommended without taking into account age, weight, or medical condition.What are the appropriate circumstances for surgery? Question 18: When rheumatoid arthritis doesn't respond to NSAIDs and 40-120 mg of methylprednisolone depot, methotrexate treatment is usually started.How long should methotrexate treatment be continued in the event that remission is induced?Will the patient, who is now in remission, receive ongoing treatment? Question 19: In rheumatoid arthritis, what is the dosage and schedule for folinic acid rescue following methotrexate? 20. QuestionIn the case of rheumatoid arthritis, what are the signs of remission?Is it the normalization of the erythrocyte sedimentation rate (ESR) or improvement in clinical condition?2.When rheumatoid arthritis goes into remission, does the rheumatoid factor disappear? Question 21: What is the connection between losing weight and rheumatoid arthritis?Can weight loss be helped by treatment while the disease is controlled?Question 22: In the treatment of rheumatoid arthritis, can oral folic acid (1 mg/day) be used in conjunction with high-dose methotrexate therapy and leucovorin rescue? Rheumatology and bone disease 88 Question 24 In what percentage of patients with psoriatic arthritis does the arthritis begin before the onset of skin or scalp lesions? Rheumatology and bone disease 88 Question 23 How frequently should a patient, on osteoporosis prophylaxis in the form of 1000 mg calcium and 400 IU vitamin D daily for the treatment of rheumatoid arthritis, have a dual energy X-ray absorptio Question No. 25:Is Reiter's syndrome the same thing as reactive arthritis?2.Chlamydia trachomatis infection has been linked, it is said, to Reiter's disease.Is this accurate? 26. QuestionIs colchicine-induced acute joint inflammation pathognomonic of gouty arthritis?2.We are informed that joint fluid microscopy is the sole diagnostic method for gout, along with clinical examinations.What is revealed by joint fluid microscopy?Is it the same as a polarized light study that shows urate deposits in the shape of needles