Answered step by step
Verified Expert Solution
Link Copied!

Question

1 Approved Answer

Makers of generic drugs must show that they do not differ significantly from the reference drugs that they imitate. One aspect in which drugs might

Makers of generic drugs must show that they do not differ significantly from the \"reference\" drugs that they imitate. One aspect in which drugs might differ is their extent of absorption in the blood. Table 17.6 gives data taken from 20 healthy nonsmoking male subjects for one pair of drugs. This is a matched pairs design. Numbers 1 to 20 were assigned at random to the subjects. Subjects 1 to 10 received the generic drug first, and Subjects 11 to 20 received the reference drug first. In all cases, a washout period separated the two drugs so that the first had disappeared from the blood before the subject took the second. TABLE 17.6 Absorption extent for two versions of a drug a. Make a probability plot and a boxplot of the differences and see if there are any major deviations from Normality in the differences. Is it reasonable to use the t procedures? (Copy and paste the graphs that result with your answer. Make sure you have meaningful titles for your graph.) If the answer is no, do not do parts b and c. b. If your conclusion in part (a) is yes, do a 97% confidence interval about the mean difference of absorption between the reference drug and the generic drug. (Copy and paste results found in the Session window after your answer. Make sure your interpretation of the 97% confidence interval is in a complete sentence in the context of the problem.) c. If your conclusion in part (a) is yes, do the data give convincing evidence that the drugs differ in absorption at a 0.05 significance level. i. State the null and alternative hypotheses. ii. State the significance level for this problem. iii. State the test statistic. Use MINITAB to compute the test statistic and P-value. (Copy and paste the results found in the Session window after your answer. Also, use this result to answer part (iv)). iv. State the P-value. v. State whether you reject or do not reject the null hypothesis. vi. State your conclusion in context of the problem. vii. If the true mean was 0, did you make an error? If so, which error? (Answer in complete sentences. You need to explain why or why not you made an error as well as identifying the type of error (Type I or II) if you did make an error. DO NOT answer these questions with a simple "Yes" or "No"; if you do, it will be marked as incorrect.)

Step by Step Solution

There are 3 Steps involved in it

Step: 1

blur-text-image

Get Instant Access to Expert-Tailored Solutions

See step-by-step solutions with expert insights and AI powered tools for academic success

Step: 2

blur-text-image

Step: 3

blur-text-image

Ace Your Homework with AI

Get the answers you need in no time with our AI-driven, step-by-step assistance

Get Started

Recommended Textbook for

Holt Mcdougal Larson Algebra 2

Authors: HOLT MCDOUGAL

1st Edition 2012

9780547647159, 0547647158

More Books

Students also viewed these Mathematics questions

Question

(Why do you ask?) (Does that question i n t e r e s t you?)

Answered: 1 week ago