Managerial accounting Founded in 1970 in Alenon (Orne), the company MPO Fentres (Menuiserie Plastique de l'Ouest) was one of the first French companies in the PVC/carpentry sector to offer a customized service. However, at that time, in France, very little was known about PVC, carpentry and double-glazing technology: these markets were still in their infancy. It took about ten years, and two oil crises (in 1974 and especially in 1979) for the PVC window market to really take off. The commercial policy of EDF (the French public energy provider) at that time favoured the development of this product, encouraging investors to push for "all electric" installations, which would, according to the manufacturer provider, require better insulation of public buildings to reduce heat loss. Despite MPO Fentres's financial losses since the creation of the company in 1978, the managers decided to invest in new office and production buildings. From 1970 to 1997, MPO Fentres's products were rather basic. Two new product ranges were then offered by the company: a range of high quality windows made of aluminium and wood (1997) and windows featuring + super heat, with an improved insulation value, made of aluminum with a thermal break (2007). These additions to its product range were introduced in line with the company's desire to widen its target market. These two new product categories now account for 10% of the company's turnover.

11 1. Is a local corticosteroid injection in the palm effective in the case of Dupuytren's contracture? 2. Can Dupuytren's contracture occur in early or well-controlled diabetes, or is it more likely to occur in uncontrolled diabetes?

12 Besides cirrhosis of the liver and diabetes mellitus (DM), what other causes of Dupuytren's contracture are there? What is the pathophysiology behind it?

13 According to one of my lecturers, who is a very well-qualified doctor and orthopaedic specialist, there is an indirect connection between osteoarthritis and subclinical local infections (such as periodontal abscesses), changing the pH of bodily fluids. Can you explain this mechanism?

14 What do you mean by saying that in nodal osteoarthritis each joint is affected one at a time? Is it that each proximal interphalangeal (PIP) or distal interphalangeal (DIP) joint is affected alone, or that at any one time PIP or DIP joints are affected together in one or both hands?

15 What are the criteria for diagnosing osteoarthritis (OA) of the knee joint radiologically? Are changes to be expected with advancing age? To what extent would I consider it significant in those below 50 years of age? Would you give me some X-ray examples if possible?

16 1. In a young patient with osteoarthritis, does long-term treatment with paracetamol (acetaminophen) 500 mg/day, rather than ibuprofen 600 mg/day, lower the incidence of renal toxicity? 2. How great is the risk of renal toxicity with both these treatments?

17 In India, total knee replacements are being recommended for every case of severe osteoarthritis, without considering factors such as age, weight or medical condition. What are the correct indications for surgery?

18 Methotrexate therapy is usually begun in rheumatoid arthritis that doesn't respond to NSAIDs plus 40-120 mg methylprednisolone depot. If a remission is then induced, how long should methotrexate therapy be continued? Will the patient (now in remission) be given maintenance therapy?

19 What is the dose and regimen for folinic acid rescue after methotrexate in rheumatoid arthritis?

20 1. What are the indicators of remission in rheumatoid arthritis? Is it normalization of erythrocyte sedimentation rate (ESR) or clinical improvement? 2. Does the rheumatoid factor disappear during a remission of rheumatoid arthritis?