Managerial accounting Today, the continuing strong growth of the market has encouraged MPO Fentres's CEO to rethink the organisational model of its agencies. In order to improve performance and increase the commercial strength of the company, an audit of its business performance was conducted. Internal research within the company enabled the identification of tasks conducted by employees, and the time allocated to each task, over the course a year. The results are as follows. Each year, a salesperson has two weeks of training and five weeks of paid holidays (in accordance with employment law). Two weeks of their annual working time is devoted to attending trade fairs. In addition, the average salesperson is absent one week per year for personal reasons. In terms of the organization of their five-day working week, the Director observed that one day is devoted to purely administrative tasks (making appointments and reporting activities). For the remaining four days of the week, based on a working day of 11 hours, one hour is devoted to the management of administrative problems and urgent tasks, and one hour is taken as a lunch break. In terms of customer contacts, information obtained from sales staff showed that the average sale is concluded at the end of the third meeting, and that such meetings last on average about an hour

41 What are the clinical features of a ruptured sinus of Valsalva?

42 Does dobutamine (dose range 2.5-10 g/kg/min) cause significant tachycardia?

43 Are beta-blockers indicated in heart failure; if yes, in all cases or in selected cases?

44 Why does long-term treatment by digitalis cause gynaecomastia?

45 Why do toxic doses of digoxin (which cause a decrease in excitability of cardiac tissue) cause arrhythmias, whereas therapeutic levels of digoxin (which cause increase in excitability) cause no arrhythmias?

46 Hypokalaemia is one of the complications of digitalis. In treatment we give K. How does the hyperkalaemia enhance the digitalis toxicity?

47 Why should we measure serum potassium before we start digoxin?

48 The intravenous administration of loop diuretics such as furosemide relieves pulmonary oedema rapidly. Is this due to arteriolar vasodilatation reducing afterload which is an action that is independent of its diuretic effect? I ask this because I have been told that this drug has no effect on arterioles (except on efferent arterioles of the kidney), but rather a venodilatatory effect. What could be the cause of such different opinions?

49 There have been a number of recent publications concerning aspirin versus warfarin trials. Would you recommend prescribing warfarin for secondary prevention of coronary heart disease in patients suffering from their first myocardial infarction (MI)?

50 Is it true that in future the ApoA : ApoB ratio will be used to predict the risk of coronary artery disease more efficiently than low-density lipoprotein (LDL)?