Question
Misclassification Scenario 1: Women were asked to recall their HRT exposure experience; recall is almost never perfect. Twenty percent of women who actually had taken
Misclassification Scenario 1:
Women were asked to recall their HRT exposure experience; recall is almost never perfect. Twenty percent of women who actually had taken HRT said that they hadn't, whereas ten percent of women who actually had not taken HRT said that they had. This occurred regardless of disease status.
CHD+
CHD-
Total
HRT+
200
5110
5310
HRT-
170
5259
5429
Total
370
10369
10739
- Use the table below to calculate the 2x2 table with misclassification.
Final table with misclassification:
CHD+
CHD-
Total
HRT+
HRT-
Total
- What are the risk ratio and risk difference in the misclassified table? Calculate and interpret.
- Compare the risk ratio in question 3 to the true risk ratio in question 1. How did misclassification of the exposure independent of disease status (non-differential misclassification of exposure) affect the estimates in the study?
Misclassification Scenario 2:
Twenty percent of the nonusers with CHD were categorized as users. Everyone else was classified accurately according to the TRUTH table above.
- Is this an example of misclassification of exposure or disease?
- Fill in the table below with the misclassified 2x2 table.
CHD+
CHD-
Total
HRT+
HRT-
Total
Table with misclassification:
CHD+
CHD-
Total
HRT+
HRT-
Total
- What are the risk ratio and risk difference in the misclassified table? Calculate and interpret.
- How did this misclassification affect the estimates in the study?
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