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More Info for the Journal Article (Dexamethasone in Hospitalized Patients with COVID-19-Preliminary Report (Recovery NEJM 2020) can be found in the supplemental Info. Complete the

More Info for the Journal Article (Dexamethasone in Hospitalized Patients with COVID-19-Preliminary Report (Recovery NEJM 2020) can be found in the supplemental Info.

Complete the Li study on Recovery NEJM 2020

Study Title

Dexamethasone in Hospitalized Patients with Covid-19

Citation

RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med. 2020 Jul 17:NEJMoa2021436. doi: 10.1056/NEJMoa2021436. Epub ahead of print. PMID: 32678530; PMCID: PMC7383595.

Background

Current standard of care or guidelines

Rationale for study

Previous or related studies

Methods

Type of study (randomized, blinded, controlled, cohort, etc)

Hypothesis and null hypothesis

Study centers and dates

Inclusion and exclusion criteria

Planned sample size and statistical power

Assignment

Method of study group assignment

Description of study regimen, duration, washout period, masking, blinding etc.

Follow-up and assessment of adherence to study regimen

Assessment (Do NOT include results here)

Primary endpoint

Secondary endpoint(s)

Safety endpoint(s)

Statistical analysis methods include discussion of appropriateness of methods

Results

Patients include discussion of:

  • Number enrolled and number completing study
  • Baseline characteristics
  • Distribution of patients within study groups (bias?)
  • Reasons for study dropouts
  • Adherence

Achievement of primary endpoint

Achievement of secondary endpoint(s)

Safety endpoints

Interpretation

Author conclusions include discussion of validity of conclusions

Journal club leaders conclusions

Ethics of study

Limitations and strengths of study

Sources of bias and methods to overcome bias

Extrapolation

Discussion of appropriateness of trial regimen and duration

Clinical significance and potential impact on current practice

Additional areas of study

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