Question
More Info for the Journal Article (Dexamethasone in Hospitalized Patients with COVID-19-Preliminary Report (Recovery NEJM 2020) can be found in the supplemental Info. Complete the
More Info for the Journal Article (Dexamethasone in Hospitalized Patients with COVID-19-Preliminary Report (Recovery NEJM 2020) can be found in the supplemental Info.
Complete the Li study on Recovery NEJM 2020
| Study Title | Dexamethasone in Hospitalized Patients with Covid-19 | |
| Citation | RECOVERY Collaborative Group, Horby P, Lim WS, Emberson JR, Mafham M, Bell JL, Linsell L, Staplin N, Brightling C, Ustianowski A, Elmahi E, Prudon B, Green C, Felton T, Chadwick D, Rege K, Fegan C, Chappell LC, Faust SN, Jaki T, Jeffery K, Montgomery A, Rowan K, Juszczak E, Baillie JK, Haynes R, Landray MJ. Dexamethasone in Hospitalized Patients with Covid-19 - Preliminary Report. N Engl J Med. 2020 Jul 17:NEJMoa2021436. doi: 10.1056/NEJMoa2021436. Epub ahead of print. PMID: 32678530; PMCID: PMC7383595. | |
| Background | ||
| Current standard of care or guidelines | ||
| Rationale for study | ||
| Previous or related studies | ||
| Methods | ||
| Type of study (randomized, blinded, controlled, cohort, etc) | ||
| Hypothesis and null hypothesis | ||
| Study centers and dates | ||
| Inclusion and exclusion criteria | ||
| Planned sample size and statistical power | ||
| Assignment | ||
| Method of study group assignment | ||
| Description of study regimen, duration, washout period, masking, blinding etc. | ||
| Follow-up and assessment of adherence to study regimen | ||
| Assessment (Do NOT include results here) | ||
| Primary endpoint | ||
| Secondary endpoint(s) | ||
| Safety endpoint(s) | ||
| Statistical analysis methods include discussion of appropriateness of methods | ||
| Results | ||
| Patients include discussion of:
| ||
| Achievement of primary endpoint | ||
| Achievement of secondary endpoint(s) | ||
| Safety endpoints | ||
| Interpretation | ||
| Author conclusions include discussion of validity of conclusions | ||
| Journal club leaders conclusions | ||
| Ethics of study | ||
| Limitations and strengths of study | ||
| Sources of bias and methods to overcome bias | ||
| Extrapolation | ||
| Discussion of appropriateness of trial regimen and duration | ||
| Clinical significance and potential impact on current practice | ||
| Additional areas of study | ||
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