multiple myeloma or blood plasma cancer is characterized by increased blood vessel formulation in the bone marrow that is a prognostic factor in survival. One treatment approach used for multiple myeloma is stem cell transplantation with the patient's own stem cells. The following data represents the bone marrow microvessel density for a sample of 7 patients who had a complete response to a stem cell transplant as measured by blood and urine tests. Two measurements were taken: the first immediately prior to the stem cell transplant and the second at the time of the complete response. Patient 1 2 3 4 5 6 7 Before158 189 202 353 416 426 441 After 284 214 101 227 90 176 290

If we wish to determine if the mean bone marrow microvessels density is higher before the stem cell transplant than after the stem cell transplant, the alternate hypothesis would be? A.) H1:ud=0 B.) H1:ud>0 C.) H1:ud-<0 d.) h1:ud =/0