n randomized, double-blind clinical trials of a new vaccine,

infants

were randomly divided into two groups. Subjects in group 1 received the new vaccine while subjects in group 2 received a control vaccine. After the second dose,

102

of

423

subjects in the experimental group (group 1) experienced

fever

as a side effect. After the second dose,

101

of

646

of the subjects in the control group (group 2) experienced

fever

as a side effect. Does the evidence suggest that a higher proportion of subjects in group 1 experienced fever as a side effect than subjects in group 2 at the

=0.01

level of significance?

Find the test statistic for this hypothesis test.

Determine the P-value for this hypothesis test.

State the conclusion for this hypothesis test